Numerical and experimental analysis of a high-throughput blood plasma separator for point-of-care applications

Blood plasma separation from undiluted blood is an essential step in many diagnostic procedures. This study focuses on the numerical optimization of microfluidic separator (BPS) and experimental validation results to achieve portable with high purity reasonable yield. The proposed design has two parts: a microchannel for processing tank below aforementioned main channel collection. uses 3D computational fluid dynamic analysis investigate optimal ratio heights between top their geometry at various flow rates. Thereafter, are compared findings fabricated devices. These contrasted some recent reported works verify device’s contribution improvement quality quantity extracted plasma. optimized capable achieving 19% yield 77.1%, depending requirement point-of-care (POC) application. amounts could be tuned, instance 100% pure plasma, but would decrease 9%. In this study, candidate application hemostasis; therefore, BPS integrated biomimetic surface hemostasis evaluation near patients.